Blóðbankinn
Vísindarannsóknir
Rannsóknir og nýsköpun meðal grunnstoða Blóðbankans
Í Blóðbankanum fer fram öflugt rannsóknar- og nýsköpunarstarf meðal annar á sviði:
stofnfrumurannsókna
frumumeðferða
vefjaverkfræði
blóðbankafræði
Markmið rannsóknar- og nýsköpunarstarfs Blóðbankans er að brúa bilið á milli tilraunavísinda og læknisfræðilegra rannsókna og skapa jarðveg fyrir nýjungar í læknisfræði á sviði stofnfruma, vefjaverkfræði og blóðbankafræða á Íslandi. Sjá einnig myndband um rannsóknir í blóðbanka og stofnfrumufræðum .
Deild rannsókna og nýsköpunar er stýrt af Dr. Ólafi E. Sigurjónssyni prófessor við verkfræðideild Háskólans í Reykjavík og klínískum prófessor við læknadeild Háskóla Íslands.
Birtingar Blóðbankans 1951-2025
Svava Kristinsdottir, Ottar Rolfsson, Olafur Eysteinn Sigurjonsson, Sigurður Brynjolfsson, Sigrun Nanna Karlsdottir. Mechanical Properties and Microstructure of Decellularized Brown Seaweed Scaffold for Tissue Engineering. Bioengineering 12 (9), 943. 2025.
G Boretti, A Amirfallah, KJ Edmunds, H Hamzehpour, ÓE Sigurjónsson. Advancing Cartilage Tissue Engineering: A Review of 3D Bioprinting Approaches and Bioink Properties. Tissue Engineering Part B: Reviews 31 (4), 357-373. 2025
Willem Delabie, Gabriele Boretti, Stephanie A Groot, Davina Ardanary, Olafur Sigurjónsson, Thomas RL Klei, Philippe Vandekerckhove, Hendrik B Feys. Human platelet lysate standardization across three independent European blood establishments. Stem Cell Research & Therapy 16 (1), 329. 2025.
Qiang Wang, Håvard Jostein Haugen, Dirk Linke, Ståle Petter Lyngstadaas1, Ólafur Eysteinn Sigurjónsson, Qianli Ma. Impact of different chemical debridement agents on early cellular responses to Titanium dental implants: a transcriptome-based In Vitro Study on Peri-implant tissue regeneration. Colloids and Surfaces B: Biointerfaces. In press. 2025
Qianli Ma, Lya Piaia, Dagnija Loca, Kristaps Rubenis, Janis Locs, Bernd Thiede, Ólafur Eysteinn Sigurjónsson, Håvard Jostein Haugen. Soluble Proteins From Conventional and Organic Eggshell Membranes With Different Proteomic Profiles Show Similar In Vitro Biofunctions. Journal of Biomedical Materials Research Part A. 2025. 113 (1), e37848
Ozcelik F, Dundar MS, Yildirim AB, Henehan G, Vicente O, Sánchez-Alcázar JA, Gokce N, Yildirim DT, Bingol NN, Karanfilska DP, Bertelli M, Pojskic L, Ercan M, Kellermayer M, Sahin IO, Greiner-Tollersrud OK, Tan B, Martin D, Marks R, Prakash S, Yakubi M, Beccari T, Lal R, Temel SG, Fournier I, Ergoren MC, Mechler A, Salzet M, Maffia M, Danalev D, Sun Q, Nei L, Matulis D, Tapaloaga D, Janecke A, Bown J, Cruz KS, Radecka I, Ozturk C, Nalbantoglu OU, Sag SO, Ko K, Arngrimsson R, Belo I, Akalin H, Dundar M. The impact and future of artificial intelligence in medical genetics and molecular medicine: an ongoing revolution. Funct Integr Genomics. 2024 Aug 16;24(4):138. doi: 10.1007/s10142-024-01417-9.
Priyanka Sahariah, Francesco Papi, Olafur E Sigurjonsson, Rikke Loiuse Meyer, Cristina Nativi. Chitosan–saccharide conjugates for eradication of Pseudomonas aeruginosa biofilms. RSC Applied Polymers. RSC Applied Polymers Volume 2 Issue3 Pages 461-472.2024
Gabriele Boretti , Arsalan Amirfallah , Kyle J. Edmunds, Helena Hamzehpour and Ólafur E. Sigurjónsson. Mechanical and Biological Characterization of Extrusion Hydrogels in Cartilage Tissue Engineering. Tissue engineering Part B (in press)
Gabriele Boretti, Hafsteinn Esjar Baldursson, Luca Buonarrivo, Stina Simonsson, Sigurður Brynjólfsson, Paolo Gargiulo and Ólafur Eysteinn Sigurjónsson. Mechanical and Biological Characterization of Ionic and Photo-Crosslinking Effects on Gelatin-Based Hydrogel for, Cartilage Tissue Engineering Applications. Polymers 16 (19), 2741
Jóhannsson F, Yurkovich JT, Guðmundsson S, Sigurjónsson ÓE, Rolfsson Ó. Temperature Dependence of Platelet Metabolism. Metabolites. 2024 Jan 26;14(2):91. doi: 10.3390/metabo14020091.
Hamzehpour H, Óskarsdóttir Á, Jónsson H, Jónsdóttir F, Sigurjónsson ÓE, Snorradottir BS. Transdermal Drug Delivery of Tazarotene: Determining Tazarotene's Potential in Local Transdermal Therapy. Pharmaceutics. 2023 Dec 31;16(1):64. doi: 10.3390/pharmaceutics16010064.
De Korte D, Delabie W, Feys HB, Klei T, Larsen R, Sigurjónsson Ó, Sousa AP; European Blood Alliance Towards standardized human platelet lysate production in Europe: An initiative of the European Blood Alliance. Vox Sang. 2023 Dec 4. doi: 10.1111/vox.13562
Apelseth TO, Doyle B, Evans R, George C, Humbrecht C, Klei T, Najdovski T, Sigurjónsson ÓE, Wiltshire M, de Korte D. Current transfusion practice and need for new blood products to ensure blood supply for patients with major hemorrhage in Europe. Transfusion. 2023 maí;63 Suppl 3(S3):S105-S111. Epub 2023 apr. 14. doi: 10.1111/trf.17349
Boretti G, Giordano E, Ionita M, Vlasceanu GM, Sigurjónsson ÓE, Gargiulo P, Lovecchio J. Human Bone-Marrow-Derived Stem-Cell-Seeded 3D Chitosan–Gelatin–Genipin Scaffolds Show Enhanced Extracellular Matrix Mineralization When Cultured under a Perfusion Flow in Osteogenic Medium. Materials. 2023 sep. 1;16(17):5898. doi: 10.3390/ma16175898
Klei TRL, Begue S, Lotens A, Sigurjónsson ÓE, Wiltshire MD, George C, van den Burg PJM, Evans R, Larsson L, Thomas S, Najdovski T, Handke W, Eronen J, Mallas B, de Korte D. Recommendations for in vitro evaluation of blood components collected, prepared and stored in non-DEHP medical devices. Vox Sanguinis. 2023 feb.;118(2):165-177. doi: 10.1111/vox.13384
Ma Q, Rubenis K, Sigurjónsson ÓE, Hildebrand T, Standal T, Zemjane S, Locs J, Loca D, Haugen HJ. Eggshell-derived amorphous calcium phosphate: Synthesis, characterization and bio-functions as bone graft materials in novel 3D osteoblastic spheroids model. Smart Materials in Medicine. 2023 jan.;4:522-537. doi: 10.1016/j.smaim.2023.04.001
Sahariah P, Kontogianni GI, Scoulica E, Sigurjónsson ÓE, Chatzinikolaidou M. Structure-activity relationship for antibacterial chitosan carrying cationic and hydrophobic moieties. Carbohydrate Polymers. 2023 júl. 15;312:120796. 120796. doi: 10.1016/j.carbpol.2023.120796
Gestsdottir E, Magnusson MK, Lund SH, Johannsdottir V, Jonsson T, Gudmundsson S, Halldorsdottir AM. Monitoring iron stores in Icelandic blood donors from 1997 through 2019. Transfus Med. 2022 Apr;32(2):128-134.
Towards new assessment of knee cartilage degeneration. Aubonnet, Romain; Ramos, Jorgelina; Recenti, Marco; Jacob, Deborah; Ciliberti, Federica Kiyomi; Guerrini, Lorena; Gislason, Magnus; Sigurjonsson, Olafur; Tsirilaki, Mariella; Jonsson jr, Halldor; Gargiulo, Paolo. Cartilage 2022 Dec 21;19476035221144746. doi: 10.1177/19476035221144746.
Protein Concentrations in Stored Pooled Platelet Concentrates Treated with Pathogen Inactivation by Amotosalen Plus Ultraviolet a Illumination. NA Arnason, F Johannsson, R Landrö, B Hardarsson, S Gudmundsson, Pathogens 11 (3), 350, 2022. https://doi.org/10.3390/pathogens11030350
Universal tumor screening in a population with MSH6-and PMS2-associated Lynch syndrome. Haukur Einarsson, Johanna Run Runarsdottir, Thordur Tryggvason, Petur Snaebjornsson, Agnes Smaradottir, Vigdis Stefansdottir, Asgeir Thoroddsen, Reynir Arngrimsson, Jon Gunnlaugur Jonasson, Sigurdis Haraldsdottir. Genetics in Medicine 24 (5), 999-1007
Brynjolfsson SF, Sigurgrimsdottir H, Einarsdottir ED, Bjornsdottir GA, Armannsdottir B, Baldvinsdottir GE, Bjarnason A, Gudlaugsson O, Gudmundsson S, Sigurdardottir ST, Love A, Kristinsson KG, Ludviksson BR. Detailed Multiplex Analysis of SARS-CoV-2 Specific Antibodies in COVID-19 Disease. Front Immunol. 2021 Jun 10;12:695230. doi: 10.3389/fimmu.2021.695230.
Clausen FB, Hellberg Å, Bein G, Bugert P, Schwartz D, Drnovsek TD, Finning K, Guz K, Haimila K, Henny C, O'Brien H, Orzinska A, Sørensen K, Thorlacius S, Wikman A, Denomme GA, Flegel WA, Gassner C, de Haas M, Hyland C, Ji Y, Lane WJ, Nogués N, Olsson ML, Peyrard T, van der Schoot CE, Weinstock C, Legler T. Recommendation for validation and quality assurance of non-invasive prenatal testing for foetal blood groups and implications for IVD risk classification according to EU regulations. Vox Sang. 2021 Jun 21. doi: 10.1111/vox.13172.
Deak D, Gorcea-Andronic N, Sas V, Teodorescu P, Constantinescu C, Iluta S, Pasca S, Hotea I, Turcas C, Moisoiu V, Zimta AA, Galdean S, Steinheber J, Rus I, Rauch S, Richlitzki C, Munteanu R, Jurj A, Petrushev B, Selicean C, Marian M, Soritau O, Andries A, Roman A, Dima D, Tanase A, Sigurjonsson O, Tomuleasa C. A narrative review of central nervous system involvement in acute leukemias. Ann Transl Med. 2021 Jan;9(1):68. doi: 10.21037/atm-20-3140.
Milewska A, Sigurjonsson OE, Leosson K. SERS Imaging of Mesenchymal Stromal Cell Differentiation. ACS Applied Bio Materials. 2021;4(6):4999-5007.doi:10.1021/acsabm.1c00286.
Sigmarsdottir TB, McGarrity S, Yurkovich JT, Rolfsson Ó, Sigurjónsson ÓE. Analyzing Metabolic States of Adipogenic and Osteogenic Differentiation in Human Mesenchymal Stem Cells via Genome Scale Metabolic Model Reconstruction. Front Cell Dev Biol. 2021;9:642681. Published 2021 Jun 4. doi:10.3389/fcell.2021.642681
Živanović V, Milewska A, Leosson K, Kneipp J. Molecular Structure and Interactions of Lipids in the Outer Membrane of Living Cells Based on Surface-Enhanced Raman Scattering and Liposome Models. Anal Chem. 2021;93(29):10106-10113. doi:10.1021/acs.analchem.1c00964
Sigmarsdottir TB, McGarrity S, de Lomana ALG, Kotronoulas A, Sigurdsson S, Yurkovich JT, Rolfsson O, Sigurjonsson OE. Metabolic and Transcriptional Changes across Osteogenic Differentiation of Mesenchymal Stromal Cells. Bioengineering (Basel). 2021 Dec 10;8(12):208. doi: 10.3390/bioengineering8120208. PMID: 34940360; PMCID: PMC8698318.
Metabolic and Transcriptional Changes across Osteogenic Differentiation of Mesenchymal Stromal Cells. Sigmarsdottir TB, McGarrity S, de Lomana ALG, Kotronoulas A, Sigurdsson S, Yurkovich JT, Rolfsson O, Sigurjonsson OE. Bioengineering (Basel). 2021 Dec 10;8(12):208. doi: 10.3390/bioengineering8120208.
Dalma Deak, Nicolae Gorcea-Andronic, Valentina Sas, Patric Teodorescu, Catalin Constantinescu, Sabina Iluta, Sergiu Pasca, Ionut Hotea, Cristina Turcas, Vlad Moisoiu, Alina-Andreea Zimta, Simona Galdean, Jakob Steinheber, Ioana Rus, Sebastian Rauch, Cedric Richlitzki, Raluca Munteanu, Ancuta Jurj, Bobe Petrushev, Cristina Selicean, Mirela Marian, Olga Soritau, Alexandra Andries, Andrei Roman, Delia Dima, Alina Tanase, Olafur Sigurjonsson and Ciprian Tomuleasacorresponding . A narrative review of central nervous system involvement in acute leukemias . Ann Transl Med. 2021 Jan; 9(1): 68. doi: 10.2137/atm-20-3140
SERS Imaging of Mesenchymal Stromal Cell Differentiation. A Milewska, OE Sigurjonsson, K Leosson. ACS CS Appl. Bio Mater. 2021, 4, 6, 4999–5007. Doi: 10.1021/acsabm.1c00286
Analyzing metabolic states of adipogenic and osteogenic differentiation in human mesenchymal stem cells via genome scale metabolic model reconstruction. TB Sigmarsdottir, S McGarrity, JT Yurkovich, Ó Rolfsson, ÓE Sigurjónsson. Front. Cell Dev. Biol., 04 June 2021. https://doi.org/10.3389/fcell.2021.642681
Marta Mikaelsdottir, Brynjar Vidarsson, Gudmundur Runarsson, Una Bjarnadottir, Pall T. Onundarson Olafur E. Sigurjonsson, Anna M. Halldorsdottir. A comparison of platelet quality between platelets from healthy donors and hereditary hemochromatosis donors over seven‐day storage. Transfusion, First published: 09 November 2020. https://doi.org/10.1111/trf.16176
Marta Mikaelsdottir, Brynjar Vidarsson, Gudmundur Runarsson, Una Bjarnadottir, Pall T. Onundarson Olafur E. Sigurjonsson, Anna M. Halldorsdottir. A comparison of platelet quality between platelets from healthy donors and hereditary hemochromatosis donors over seven‐day storage. Transfusion, First published: 09 November 2020. https://doi.org/10.1111/trf.16176
B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974? Minodora Desmirean , Sebastian Rauch, Ancuta Jurj, Sergiu Pasca, Sabina Iluta, Patric Teodorescu, Cristian Berce , Alina-Andreea Zimta, Adrian-Bogdan Tigu, Cristian Moldovan, Irene Paris, Jakob Steinheber, Cedric Richlitzki, Catalin Constantinescu, Olafur Eysteinn Sigurjonsson, Delia Dima, Bobe Petrushev and Ciprian Tomuleasa. J. Clin. Med. 2020, 9(11), 3412; https://doi.org/10.3390/jcm9113412
Overview of the Side-Effects of FDA- and/or EMA-Approved Targeted Therapies for the Treatment of Hematological Malignancies. Catalin Constantinescu, Sergiu Pasca, Alina-Andreea Zimta,Tiberiu Tat, Ioana Rus ,Patric Teodorescu,Sabina Iluta, Alina Tanase , Anca Colita , Olafur Sigurjonsson ,Hermann Einsele and Ciprian Tomuleasa. J. Clin. Med. 2020, 9(9), 2903; https://doi.org/10.3390/jcm9092903
Rhesus D alloimmunization in pregnancy from 1996 to 2015 in Iceland: a nation-wide population study prior to routine antenatal anti-D prophylaxis.Gudlaugsson B, Hjartardottir H, Svansdottir G, Gudmundsdottir G, Kjartansson S, Jonsson T, Gudmundsson S, Halldorsdottir AM. Transfusion. 2020 Jan;60(1):175-183. https://doi.org/10.1111/trf.15635
The Malignant Role of Exosomes as Nanocarriers of Rare RNA Species. Alina-Andreea Zimta , Olafur Eysteinn Sigurjonsson, Diana Gulei and Ciprian Tomuleasa. J. Mol. Sci. 2020, 21(16), 5866. https://dx.doi.org/10.3390%2Fijms21165866
Human Embryonic-Derived Mesenchymal Progenitor Cells (hES-MP Cells) are Fully Supported in Culture with Human Platelet Lysates. Jonsdottir-Buch SM, Gunnarsdottir K, Sigurjonsson OE. Bioengineering (Basel). 2020 Jul 20;7(3):E75. https://doi.org/10.3390/bioengineering7030075
Continuous renal replacement therapy in cytokine release syndrome following immunotherapy or cellular therapies? . Constantinescu C, Pasca S, Tat T, Teodorescu P, Vlad C, Iluta S, Dima D, Tomescu D, Scarlatescu E, Tanase A, Sigurjonsson OE, Colita A, Einsele H, Tomuleasa C. J Immunother Cancer. 2020 May;8(1):e000742. https://doi.org/10.1136/jitc-2020-000742
Effects of amotosalen treatment on human platelet lysate bioactivity: A proof-of-concept study. Christensen C, Jonsdottir-Buch SM, Sigurjonsson OE. PLoS One. 2020 Apr 15;15(4):e0220163. https://dx.doi.org/10.1371%2Fjournal.pone.0220163
Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative Medicine. Sigmarsdóttir Þ, McGarrity S, Rolfsson Ó, Yurkovich JT, Sigurjónsson ÓE. Front Bioeng Biotechnol. 2020; 8: 239. https://dx.doi.org/10.3389%2Ffbioe.2020.00239
Visualizing metabolic network dynamics through time-series metabolomic data. Buchweitz LF, Yurkovich JT, Blessing C, Kohler V, Schwarzkopf F, King ZA, Yang L, Jóhannsson F, Sigurjónsson ÓE, Rolfsson Ó, Heinrich J, Dräger A. BMC Bioinformatics. 2020 Apr 3;21(1):130. https://doi.org/10.1186/s12859-020-3415-z
Metabolomics study of platelet concentrates photochemically treated with amotosalen and UVA light for pathogen inactivation. Jóhannsson F, Árnason NÁ, Landrö R, Guðmundsson S, Sigurjonsson ÓE, Rolfsson Ó.Transfusion. 2020 Feb;60(2):367-377. https://doi.org/10.1111/trf.15610
Stefaniak, M, Gudjonsdottir M and Sigurjonsson OE. Fucoidan oligosaccharides-gold from the sea. Encyclopedia of Marine Biotechnology, Chapter 46. ISBN: 978-1-119-14377-2Wiley-Blackwell. https://doi.org/10.1002/9781119143802.ch46
Johannesdottir BK, Johannesdottir U, Jonsson T, Lund SH, Mogensen B, Gudbjartsson T. High Mortality from Major Vascular Trauma in Traffic Accidents: A Population-Based Study. Scand J Surg. 2020 Dec;109(4):328-335. https://doi.org/10.1177/1457496919863944
Sarah McGarrity, Sigurður T. Karvelsson, Olafur E. Sigurjonsson, andOttar Rolfsson. ComparativeMetabolic Network FluxAnalysistoIdentifyDifferencesinCellularMetabolism. MethodsandProtocols, MethodsinMolecularBiology, vol. 2088: 223-269. Springer 2019. https://doi.org/10.1007/978-1-0716-0159-4_11
Gold nanoislandsubstrates for SERS characterization of culturedcells.Milewska A, Zivanovic V, Merk V, Arnalds UB, Sigurjónsson ÓE, Kneipp J, Leosson K.BiomedOpt Express. 2019 Nov 8;10(12):6172-6188. https://doi.org/10.1364/boe.10.006172
A standalone bioreactor system to deliver compressive load under perfusion flow to hBMSC-seeded 3D chitosan-graphene templates. Lovecchio J, Gargiulo P, Vargas Luna JL, Giordano E, Sigurjónsson ÓE. Sci Rep. 2019 Nov 14;9(1):16854. https://doi.org/10.1038/s41598-019-53319-7
Pathogen inactivation with amotosalen plus UVA illumination minimally impacts microRNA expression in platelets during storage under standard blood banking conditions. Arnason NA, Johannson F, Landrö R, Hardarsson B, Irsch J, Gudmundsson S, Rolfsson O, Sigurjonsson OE. Transfusion. 2019 Dec;59(12):3727-3735. https://doi.org/10.1111/trf.15575
A Milewska, AS Ingason, OE Sigurjonsson, K Leosson. Herding cats: managing gold atoms on common transparent dielectrics. Optical Materials Express. 2019, 9 (1), 112-119. https://doi.org/10.1364/OME.9.000112
Stefaniak, M. M., Marteinsdottir, G., Bravo, E., Sigurjonsson, O. E., & Kristbergsson, K. (2019). Determination of bioactiveproperties of extracts from Icelandicediblebrownseaweedsugarkelp (Saccharinalatissima)Functional Foods in Health andDisease 9 (1), 1-15. https://doi.org/10.31989/ffhd.v9i1.546
Clausen FB, Barrett AN, Akkok CA, Armstrong-Fisher S, Bergstrom KD, Boggione CT, Baevre MS, Choolani M, Christiansen M, Cotorruelo C, Drnovsek TD, Finning K, Guz K, de Haas M, Haimila K, Halldorsdottir AM, Hellberg A, Henny C, Holmertz C, Al Houghton J, Hyland C, Jakobsen MA, Kvitland MA, Lambert M, Legler TJ, Liew Y-W, Muniz-Diaz E, Mortberg A, Niederhauser C, Nogues N, Nystrom S, Olsson ML, Orzinska A, Parks M, Rietkotter E, Ryan H, Sachs UJ, van der Schoot E, Silcock L, Steffensen R, Sulin K, Sorensen AS, Tarrant S, Thorlacius S, Wienzek-Lischka S, Wikman A, Wulf-Johansson H, Zupan M, Dziegiel MH. VoxSang. 2019 May;114(4):386-393. https://doi.org/10.1111/vox.12768
MG, Jonsson T, Halldorsdottir AM. CirculatingplasmamicroRNAsasbiomarkers for iron status inblooddonors. TransfusionMedicine. 2019 Apr;29 Suppl 1:52-58. https://doi.org/10.1111/tme.12554
Thorvaldsson HH, Vidarsson B, Sveinsdottir SV, Olafsson GB, Halldorsdottir AM. Redbloodcellutilizationandtransfusiontriggersinpatientsdiagnosed with chroniclymphocyticleukaemiain Iceland 2003-2016.Vox Sang. 2019 Jul;114(5):495-504. https://doi.org/10.1111/vox.12775
Gudmundsson B, Thormar HG, Sigurdsson A, Dankers W, Steinarsdottir M, Hermanowicz S, Sigurdsson S, Olafsson D, Halldorsdottir AM, Meyn S, Jonsson JJ. Northern lights assay: a versatile method for comprehensive detection of DNA damage. Nucleic Acids Res. 2018 Nov 16;46(20):e118. https://doi.org/10.1093/nar/gky645
Anna Margret Halldorsdottir, Sveinlaug Atladottir, Margret A. Thorsteinsdottir, Niels A. Arnason, Gudmundur Runarsson, Torbjorn Jonsson, Olafur E. Sigurjonsson, Sigrun Reykdal. To wash or not to wash?: Comparison of patient outcome after infusion of cryopreserved autologous hematopoietic stem cells before and after the replacement of manual washing by bedside thawing. Acta Hematalogica 2 018;140(3):169-175. https://doi.org/10.1159/000492741
Jóhannsson F, Guðmundsson S, Paglia G, Guðmundsson S, Palsson B, Sigurjónsson ÓE, Rolfsson Ó Systems analysis of metabolism in platelet concentrates during storage in platelet additive solution. Biochem J. 2018 Jul 17;475(13):2225-2240. doi: https://doi.org/10.1042/bcj20170921
POGZ Is Required for Silencing Mouse Embryonic β-like Hemoglobin and Human Fetal Hemoglobin Expression. Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Kimberly D. Klarmann, Satyendra K. Singh, Lei Sun, Shweta Singh, Yang Du, Vincenzo Coppola, Luke Stockwin, Nhu Nguyen, Lino Tessarollo, Leifur Thorsteinsson, Olafur E. Sigurjonsson, Sveinn Gudmundsson, Thorunn Rafnar, John F. Tisdale, Jonathan R. Keller. Cell Report; Volume 23, Issue 11, p3236–3248, 12 June 2018. https://doi.org/10.1016/j.celrep.2018.05.043
Santos S, Sigurjonsson OE, Custodio C, Mano JF. Tissue Eng Part B Rev. Blood plasma derivatives for tissue engineering and regenerative medicine therapies. 2018 May 8. https://doi.org/10.1089/ten.teb.2018.0008
Yurkovich JT, Bordbar A, Sigurjónsson ÓE, Palsson BO. Systems biology as an emerging paradigm in transfusion medicine. BMC Syst Biol. 2018 Mar 7;12(1):31. https://doi.org/10.1186/s12918-018-0558-x
Strunk, Dirk, Lozano, Miguel, Marks, Denese, Loh, Yen Siew, Gstraunthaler , Gerhard. Schennach, Harald, Rohde, Eva, Laner-Plamberger, Sandra, Nystedt , Johanna, Korhonen, Matti, Bieback, Karen, Schäfer, Richard, Bakchoul, Tamam, Waidmann, Marc, Lotfi, Ramin, Rojewski, Marcus, Schrezenmeier, Hubert;, Jonsdottir-Buch, Sandra, Montazeri, Helena, Sigurjónsson, Olafur, Introna, Martino, Capelli, Chiara, Falanga, Anna, Iudicone, Paola, Fioravanti, Daniela, Pierelli, Luca, Takanashi, Minoko, López-Villar, Olga, Burnouf, Thierry, Reems, Jo-Anna, Pierce, Jan, Preslar, Amber, Schallmoser, Katharina. International Forum on GMP-grade human platelet lysate for cell propagation. Vox Sang. Vox Sang. 2018 Jan;113(1):e1-e25. https://doi.org/10.1111/vox.12593
Strunk, Dirk, Lozano, Miguel, Marks, Denese, Loh, Yen Siew, Gstraunthaler , Gerhard. Schennach, Harald, Rohde, Eva, Laner-Plamberger, Sandra, Nystedt , Johanna, Korhonen, Matti, Bieback, Karen, Schäfer, Richard, Bakchoul, Tamam, Waidmann, Marc, Lotfi, Ramin, Rojewski, Marcus, Schrezenmeier, Hubert;, Jonsdottir-Buch, Sandra, Montazeri, Helena, Sigurjónsson, Olafur, Introna, Martino, Capelli, Chiara, Falanga, Anna, Iudicone, Paola, Fioravanti, Daniela, Pierelli, Luca, Takanashi, Minoko, López-Villar, Olga, Burnouf, Thierry, Reems, Jo-Anna, Pierce, Jan, Preslar, Amber, Schallmoser, Katharina. International Forum on GMP-grade human platelet lysate for cell propagation: Summary. Vox Sang. Vox Sang. 2018 Jan;113(1):80-87. https://doi.org/10.1111/vox.12594
Marta Mikaelsdottir, Brynjar Vidarsson, Gudmundur Runarsson, Una Bjarnadottir, Pall T. Onundarson Olafur E. Sigurjonsson, Anna M. Halldorsdottir. A comparison of platelet quality between platelets from healthy donors and hereditary hemochromatosis donors over seven‐day storage. Transfusion, First published: 09 November 2020. https://doi.org/10.1111/trf.16176
B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974? Minodora Desmirean , Sebastian Rauch, Ancuta Jurj, Sergiu Pasca, Sabina Iluta, Patric Teodorescu, Cristian Berce , Alina-Andreea Zimta, Adrian-Bogdan Tigu, Cristian Moldovan, Irene Paris, Jakob Steinheber, Cedric Richlitzki, Catalin Constantinescu, Olafur Eysteinn Sigurjonsson, Delia Dima, Bobe Petrushev and Ciprian Tomuleasa. J. Clin. Med. 2020, 9(11), 3412; https://doi.org/10.3390/jcm9113412
Overview of the Side-Effects of FDA- and/or EMA-Approved Targeted Therapies for the Treatment of Hematological Malignancies. Catalin Constantinescu, Sergiu Pasca, Alina-Andreea Zimta,Tiberiu Tat, Ioana Rus ,Patric Teodorescu,Sabina Iluta, Alina Tanase , Anca Colita , Olafur Sigurjonsson ,Hermann Einsele and Ciprian Tomuleasa. J. Clin. Med. 2020, 9(9), 2903; hhttps://doi.org/10.3390/jcm9092903
Rhesus D alloimmunization in pregnancy from 1996 to 2015 in Iceland: a nation-wide population study prior to routine antenatal anti-D prophylaxis.Gudlaugsson B, Hjartardottir H, Svansdottir G, Gudmundsdottir G, Kjartansson S, Jonsson T, Gudmundsson S, Halldorsdottir AM. Transfusion. 2020 Jan;60(1):175-183. https://doi.org/10.1111/trf.15635
The Malignant Role of Exosomes as Nanocarriers of Rare RNA Species. Alina-Andreea Zimta , Olafur Eysteinn Sigurjonsson, Diana Gulei and Ciprian Tomuleasa. J. Mol. Sci. 2020, 21(16), 5866. https://dx.doi.org/10.3390%2Fijms21165866
Human Embryonic-Derived Mesenchymal Progenitor Cells (hES-MP Cells) are Fully Supported in Culture with Human Platelet Lysates. Jonsdottir-Buch SM, Gunnarsdottir K, Sigurjonsson OE. Bioengineering (Basel). 2020 Jul 20;7(3):E75. https://doi.org/10.3390/bioengineering7030075
Continuous renal replacement therapy in cytokine release syndrome following immunotherapy or cellular therapies? . Constantinescu C, Pasca S, Tat T, Teodorescu P, Vlad C, Iluta S, Dima D, Tomescu D, Scarlatescu E, Tanase A, Sigurjonsson OE, Colita A, Einsele H, Tomuleasa C. J Immunother Cancer. 2020 May;8(1):e000742. https://doi.org/10.1136/jitc-2020-000742
Effects of amotosalen treatment on human platelet lysate bioactivity: A proof-of-concept study. Christensen C, Jonsdottir-Buch SM, Sigurjonsson OE. PLoS One. 2020 Apr 15;15(4):e0220163. https://dx.doi.org/10.1371%2Fjournal.pone.0220163
Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative Medicine. Sigmarsdóttir Þ, McGarrity S, Rolfsson Ó, Yurkovich JT, Sigurjónsson ÓE. Front Bioeng Biotechnol. 2020; 8: 239. https://dx.doi.org/10.3389%2Ffbioe.2020.00239
Visualizing metabolic network dynamics through time-series metabolomic data. Buchweitz LF, Yurkovich JT, Blessing C, Kohler V, Schwarzkopf F, King ZA, Yang L, Jóhannsson F, Sigurjónsson ÓE, Rolfsson Ó, Heinrich J, Dräger A. BMC Bioinformatics. 2020 Apr 3;21(1):130. https://doi.org/10.1186/s12859-020-3415-z
Metabolomics study of platelet concentrates photochemically treated with amotosalen and UVA light for pathogen inactivation. Jóhannsson F, Árnason NÁ, Landrö R, Guðmundsson S, Sigurjonsson ÓE, Rolfsson Ó.Transfusion. 2020 Feb;60(2):367-377. https://doi.org/10.1111/trf.15610
Stefaniak, M, Gudjonsdottir M and Sigurjonsson OE. Fucoidan oligosaccharides-gold from the sea. Encyclopedia of Marine Biotechnology, Chapter 46. ISBN: 978-1-119-14377-2Wiley-Blackwell. https://doi.org/10.1002/9781119143802.ch46
Johannesdottir BK, Johannesdottir U, Jonsson T, Lund SH, Mogensen B, Gudbjartsson T. High Mortality from Major Vascular Trauma in Traffic Accidents: A Population-Based Study. Scand J Surg. 2020 Dec;109(4):328-335. https://doi.org/10.1177/1457496919863944
2016
Jóhannsdóttir V, Gudmundsson S, Möller E, Aspelund T, Zoëga H.Blood donors in Iceland: a nationwide population-based study from 2005 to 2013. Transfusion. 2016 Jun;56(6 Pt 2):1654-61. https://doi.org/10.1111/trf.13522
Priyanka Sahariah, Bergthóra S. Snorradóttir, Martha Á. Hjálmarsdóttir, Ólafur E. Sigurjónsson and Már Másson Experimental design for determining quantitative structure activity relationship for antibacterial chitosan derivatives J. Mater. Chem. B, 2016,4, 4762-4770. https://doi.org/10.1039/c6tb00546b
Giuseppe Paglia, Angelo D’Alessandro, Óttar Rolfsson, Ólafur E. Sigurjónsson, Aarash Bordbar, Sirus Palsson, Travis Nemkov, Kirk C. Hansen, Sveinn Gudmundsson, Bernhard O. Palsson. Biomarkers defining the metabolic age of red blood cells during cold storage. Blood 2016 Sep 29;128(13):e43-50. https://doi.org/10.1182/blood-2016-06-721688
Giuseppe Paglia, Ólafur E Sigurjónsson, Aarash Bordbar, Óttar Rolfsson, Manuela Magnusdottir, Sirus Palsson, Kristine Wichuk, Sveinn Gudmundsson, Bernhard O Palsson. Metabolic fate of adenine in red blood cells during storage in SAGM solution. Transfusion. 2016 Oct;56(10):2538-2547. https://doi.org/10.1111/trf.13740
Bordbar, P.I. Johansson, G. Paglia, S.J. Harrison, K. Wichuk, M. Magnusdottir, S. Valgeirsdottir, M. GybelBrask, S.R. Ostrowski, S. Palsson, O. Rolfsson, O.E. Sigurjonsson, S. Gudmundsson, B.O. Palsson. Identified metabolomic signature for assessing red blood cell unit quality is associated with endothelial damage and clinical outcomes. Transfusion. 2016 Apr;56(4):852-62. https://doi.org/10.1111/trf.13460
Nikhil N. Kulkarni, Hörður Ingi Gunnarsson, Zhiqian Yi, Steinunn Gudmundsdottir, Olafur E Sigurjonsson, Gudmundur H. Gudmundsson. Glucocorticoid dexamethasone down-regulates basal and vitamin D3 induced cathelicidin expression in human monocytes and bronchial epithelial cell line. Immunobiology. 2016 Feb;221(2):245-52. https://doi.org/10.1016/j.imbio.2015.09.001
Lovecchio J, Gargiulo P, Sigurjonsson OE. Biomedical Engineering; Introduction to current approaches. Chapter: Bone tissue engineering and bioreactors. 2016, Ditura PRINTECH ISBN:978-606-23-0582.
Montazeri H, Jonsdottir SM and Sigurjonsson OE. Biomedical Engineering; Introduction to current approaches. Chapter: Bone tissue engineering and bioreactor. 2016, Ditura PRINTECH ISBN:978-606-23- 0582.
2015
Priyanka Sahariah, Kasper K. Sørensen, Martha Á. Hjálmarsdóttir, Olafur E. Sigurjonsson, Knud J. Jensen, Már Mássona and Mikkel B. Thygesen. Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers. Chem. Commun (Camb). 2015 Jul 25;51(58):11611-4. https://doi.org/10.1039/c5cc04010h
Priyanka Sahariah, Berglind Eva Benediktssdóttir, Martha Hjálmarsdóttir, Ólafur Eysteinn Sigurjónsson, Mikkel Boas Thygesen, Már Mássona. Impact of chain length on the Antibacterial activity and Hemocompatibility of Quaternary N-alkyl chitosan derivatives. Biomacromolecules. 2015 May 11;16(5):1449-60. https://doi.org/10.1021/acs.biomac.5b00163
Steinunn Guðmundsdottir, Ramona Lieder, Olafur E. Sigurjónsson and Petur H. Petersen. Chitosan leads to downregulation of YKL-40 and inflammasome activation in human macrophages. 2015 Aug;103(8):2778-85. https://doi.org/10.1002/jbm.a.35417
Giuseppe Paglia, Ólafur E. Sigurjónsson, Óttar Rolffson, Morten Bagge Hansen, Sveinn Guðmundsson, Bernhard Ø. Palsson. Metabolomic Analysis of Platelet During Storage: A Comparison Between Aphaeresis and Buffy Coat Derived Platelet Concentrates. Transfusion. 2015 Feb;55(2):301-13. https://doi.org/10.1111/trf.12834
Jonsdottir-Buch SM, Sigurgrímsdóttir H, Lieder R and Sigurjonsson OE Expired pathogen inactivated platelet transfusion units support mesenchymal stroma cells in culture Cell Transplant. 2015;24(8):1545- 54. https://doi.org/10.3727/096368914x683043
2014
Joseph Lovecchio, Sandra M. Jónsdóttir-Buch, Guðrún Kristín Einarsdóttir, Magnús Kjartan Gíslason, Gissur Örlygsson, Ólafur Eysteinn Sigurjónsson and Paolo Gargiulo. Assessment of Perfusion Bioreactors System Using μCT Technology and 3D Modeling Methods. Biomedizinische Technik/Biomedical Engineering Biomedizinische Technik 2014. 59(S1):302-305. https://doi.org/10.1515/bmt-2014-5003
Gislason MK, Procopio A; Orlygsson G, Sigurjonsson OE, Jonsson jr H, Gargiulo P. Finite element modelling of the distal radioulnar joint. Biomedizinische Technik/Biomedical Engineering. 2014. 59(s1):925-928. https://doi.org/10.1515/bmt-2014-5003
Giuseppe Paglia, Ólafur E. Sigurjónsson, Óttar Rolffson, Soley Valgeirsdottir, Morten Bagge Hansen, Sveinn Guðmundsson, Bernhard Ø. Palsson. Comprehensive metabolomic study of platelets reveals the expression of discrete metabolic phenotypes during storage. Transfusion. 2014 Nov;54(11):2911-23. https://doi.org/10.1111/trf.12710
Lieder R, Sigurjonsson OE.The Effect of Recombinant Human Interleukin-6 on Osteogenic Differentiation and YKL-40. Expression in Human, Bone Marrow-Derived Mesenchymal Stem Cells. Biores Open Access. 2014 Feb 1;3(1):29-34. https://doi.org/10.1089/biores.2013.0035
Agnes Czeneka, Romane Blancharde, Alexander Dejacoc, Olafur E. Sigurjonsson, Gissur Orlygsson, Paolo Gargiuloa, Christian Hellmich. Quantitative Intravoxel Analysis of microCT-scanned Resorbing Ceramic Biomaterials. Journal of Materials Research. 2014. 29 (23) 2757-2772. https://doi.org/10.1557/jmr.2014.326
Priyanka Sahariah, Vivek S. Gaware, Ramona Lieder, Sigríður Jónsdóttir, Martha Hjálmarsdóttir, Olafur Eysteinn Sigurjonsson, Már Másson. Effect of Substituent, Degree of Acetylation and Positioning of the Cationic Charge on the Antibacterial Activity of Quaternary Chitosan Derivatives. Marine Drugs. 2014. 12(8), 4635-4658. https://dx.doi.org/10.3390%2Fmd12084635
Lieder R, Darai M, Orlygsson G, Sigurjonsson OE. Solution casting of chitosan membranes for in vitro evaluation of bioactivity. Biological procedures online 2014 Feb 1;3(1):29-34. https://doi.org/10.1186/1480-9222-15-11
2013
Lieder R, and Sigurjonsson OE. Chitosan as a coating material for titanium implants.Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments, edited by Se-Kwon Kim. Chapter 22. 2013. Published by CRP press. https://doi.org/10.1201/b15636
Sigurgeirsson B, Thornorsteinsson H, Sigmundsdóttir S, Lieder R, Sveinsdóttir HS, Sigurjonsson OE, Halldórsson B, Karlsson K. Sleep-wake dynamics under extended light and extended dark conditions in adult zebrafish. Behav Brain Res. 2013 Nov 1; 256:377. https://doi.org/10.1016/j.bbr.2013.08.032
Jonsdottir-Buch SM, Lieder R, Sigurjonsson OE (2013) Platelet Lysates Produced from Expired Platelet Concentrates Support Growth and Osteogenic Differentiation of Mesenchymal Stem Cells. PLoS ONE 8(7): e68984. https://doi.org/10.1371/journal.pone.0068984
Einarsson JM, Bahrke S, Sigurdsson BT, Ng CH, Petersen PH, Sigurjonsson OE, Jonsson H Jr, Gislason J, Thormodsson FR, Peter MG. Partially acetylated chitooligosaccharides bind to YKL-40 and stimulate growth of human osteoarthritic chondrocytes. Biochem Biophys Res Commun. 2013 May 3;434(2):298- 304. https://doi.org/10.1016/j.bbrc.2013.02.122
Lieder R and Sigurjonsson OE. Stem cells and Tissue Engineering–The Ultimate Combo for Clinical Therapy? Drug Design 2013, S3. http://dx.doi.org/10.4172/2169-0138.S3-e001 Lieder R, Peteresen PH and Sigurjonsson OE. Endotoxins - the invisible companion in biomaterials research. Tissue engineering Part B: Reviews. 2013 May 3;434(2):298-304. https://doi.org/10.1089/ten.teb.2012.0636
Lieder R, Gaware VS, Thormodsson F, Einarsson JM, Ng CH, Gislason J, Masson M, Petersen PH, Sigurjonsson OE. Endotoxins affect bioactivity of chitosan derivatives in cultures of bone marrowderived human mesenchymal stem cells. Acta Biomater. 2013 Jan;9(1):4771-8. https://doi.org/10.1016/j.actbio.2012.08.043
Petursdottir D, Haraldsdottir SO, Bjarnadottir K, Jonsson T, Gislason T, Gudmundsson S, Gudbjornsson B. Sarcoid arthropathy and the association with the human leukocyte antigen. The Icelandic Sarcoidosis Study. Clin Exp Rheumatol. 2013 Sep-Oct;31(5):711-6. https://pubmed.ncbi.nlm.nih.gov/23711303/
Jorgensen GH, Gardulf A, Sigurdsson MI, Sigurdardottir ST, Thorsteinsdottir I, Gudmundsson S, Hammarström L, Ludviksson BR. Clinical symptoms in adults with selective IgA deficiency: a case-control study. J Clin Immunol. 2013 May;33(4):742-7. https://doi.org/10.1007/s10875-012-9858-x
Hreinsson JP, Kalaitzakis E, Gudmundsson S, Björnsson ES. Upper gastrointestinal bleeding: incidence, etiology and outcomes in a population-based setting. Scand J Gastroenterol. 2013 Apr;48(4):439-47. doi: 10.3109/00365521.2012.763174. https://doi.org/10.3109/00365521.2012.763174
Hreinsson JP, Gudmundsson S, Kalaitzakis E, Björnsson ES. Lower gastrointestinal bleeding: incidence, etiology, and outcomes in a population-based setting. Eur J Gastroenterol Hepatol. 2013 Jan;25(1):37- 43. https://doi.org/10.1097/meg.0b013e32835948e3
Jónsson T, Gudmundsson KG, Bjarnadóttir K, Hjálmarsdótti IB, Gudmundsson S, Arngrímsson R. Association of HLA-DRB1*01 with Dupuytren's disease. Scand J Rheumatol. 2013;42(1):45-7. https://doi.org/10.3109/03009742.2012.713982
Kolka R, Valdimarsson H, Bodvarsson M, Hardarson S, Jonsson T. Defective immunoglobulin A (IgA) glycosylation and IgA deposits in patients with IgA nephropathy. APMIS 2013 Sep;121(9):890-7. https://doi.org/10.1111/apm.12051
Gudmundsson KG, Jónsson T, Arngrímsson R. Association of Morbus Ledderhose with Dupuytren's contracture. Foot Ankle Int. 2013 Jun;34(6):841-5.Paglia G, Palsson BO, Sigurjonsson OE. Systems biology of stored blood cells: Can it help to extend the expiration date? J Proteomics. 2012: S1874-3919(12). https://doi.org/10.1016/j.jprot.2012.08.014
2012
Halasi G, Søviknes AM, Sigurjonsson OE, Glover JC. Proliferation and recapitulation of developmental patterning associated with regulative regeneration of the spinal cord neural tube. Dev Biol. 2012 May 1;365(1):118-32. https://doi.org/10.1016/j.ydbio.2012.02.012
Paglia G, Magnúsdóttir M, Thorlacius S, Sigurjónsson OE, Guðmundsson S, Palsson BØ, Thiele I. Intracellular metabolite profiling of platelets: evaluation of extraction processes and chromatographic strategies. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:111-20. https://doi.org/10.1016/j.jchromb.2012.04.026
Lieder R, Darai M, Thor MB, Ng CH, Einarsson JM, Gudmundsson S, Helgason B, Gaware VS, Másson M, Gíslason J, Orlygsson G, Sigurjónsson OE. In vitro bioactivity of different degree of deacetylation chitosan, a potential coating material for titanium implants. J Biomed Mater Res A. 2012 Dec;100(12):3392-9. https://doi.org/10.1002/jbm.a.34283
Lieder R, Thormodsson F, Ng CH, Einarsson JM, Gislason J, Petersen PH, Sigurjonsson OE. Chitosan and Chitin Hexamers affect expansion and differentiation of mesenchymal stem cells differently. Int J Biol Macromol. 2012 Nov;51(4):675-80. https://doi.org/10.1016/j.ijbiomac.2012.07.005
Lieder R, Reynisdottir SR, Thormodsson F, Chuen-How Ng, Einarsson JM, Gislason J, Bjornsson J, Gudmundsson S, Petersen PH and Sigurjonsson OE. Glucosamine increases the expression of YKL-40 and osteogenic marker genes in hMSC during osteogenic differentiation. Natural Products and Bioprospecting Volume 2, Number 2 (2012), 87-91. https://dx.doi.org/10.1007%2Fs13659-012-0017-0
Kanduri M, Marincevic M, Halldórsdóttir AM, Mansouri L, Junevik K, Ntoufa S, Kultima HG, Isaksson A, Juliusson G, Andersson PO, Ehrencrona H, Stamatopoulos K, Rosenquist R. Distinct transcriptional control in major immunogenetic subsets of chronic lymphocytic leukemia exhibiting subset-biased global DNA methylation profiles. Epigenetics. 2012 Dec 1;7(12):1435-42. https://dx.doi.org/10.4161%2Fepi.22901
2011
Halldórsdóttir AM, Lundin A, Murray F, Mansouri L, Knuutila S, Sundström C, Laurell A, Ehrencrona H, Impact of TP53 mutation and 17p deletion in mantle cell lymphoma. Leukemia. 2011 Dec;25(12):1904-8. doi: 10.1038/leu.2011.162. Epub 2011 Jul 1. https://doi.org/10.1038/leu.2011.162
Halldórsdóttir AM, Sander B, Göransson H, Isaksson A, Kimby E, Mansouri M, Rosenquist R, Ehrencrona H. High-resolution genomic screening in mantle cell lymphoma--specific changes correlate with genomic complexity, the proliferation signature and survival. Genes Chromosomes Cancer. 2011 Feb;50(2):113- 21. https://doi.org/10.1002/gcc.20836
Halldorsdottir AM, Kanduri M, Marincevic M, Mansouri L, Isaksson A, Goransson H, Axelsson T, Agarwal P, Jernberg-Wiklund H, Stamatopoulos K, Sander B, Ehrencrona H, Rosenquist R. Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia. Am J Hematol. 2012;87(4):361-7. https://doi.org/10.1002/ajh.23115
Jorgensen GH, Ornolfsson AE, Johannesson A, Gudmundsson S, Janzi M, Wang N, Hammarstrom L, Ludviksson BR. Association of immunoglobulin A deficiency and elevated thyrotropin-receptor autoantibodies in two Nordic countries. Hum Immunol 2011;72(2):166-72. https://doi.org/10.1016/j.humimm.2010.10.014
2010
Gunnar Tómasson, Thor Aspelund, Þorbjörn Jónsson, Helgi Valdimarsson, David T. Felson, Vilmundur Guðnason. Effect of rheumatoid factor on mortality and coronary heart disease. Ann Rheum Dis 2010; 69 (9): 1649-54. https://doi.org/10.1136/ard.2009.110536
2009
Jorgensen GH, Thorsteinsdottir I, Gudmundsson S, Hammarstrom L, Ludviksson BR. Familial aggregation of IgAD and autoimmunity. Clin Immunol 2009;131(2):233-9. The effect of rheumatoid factor on mortality and coronary heart disease. Gunnar Tómasson, Thor Aspelund, Þorbjörn Jónsson, Helgi Valdimarsson, David T Felson, Vilmundur Guðnason. Ann Rheum Dis 2009 Published Online: 23 July 2009
doi:10.1136/ard.2009.110536. https://doi.org/10.1016/j.clim.2008.11.013Jorgensen GH, Thorsteinsdottir I, Gudmundsson S, Hammarstrom L, Ludviksson BR. Familial aggregation of IgAD and autoimmunity. Clin Immunol. 2009 May;131(2):233-9.
https://doi.org/10.1016/j.clim.2008.11.013
2008
Halldórsdóttir AM, Frühwirth M, Deutsch A, Aigelsreiter A, Beham-Schmid C, Agnarsson BA, Neumeister P, Richard Burack W. Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma. Leuk Res. 2008 Jul;32(7):1015-21. https://doi.org/10.1016/j.leukres.2007.11.028
2007
Halldorsdottir AM, Grenache DG, Snyder J, Chowning RT, Gronowski AM. Comparison of various methods for amniotic fluid DeltaOD450 bilirubin measurement. Clin Chim Acta. 2008 Mar;389(1-2):160- 3. Epub 2007 Nov 13. https://doi.org/10.1016/j.cca.2007.11.004
Grogaard HK, Sigurjonsson OE, Brekke M, Klov E. Solberg KL, Lyberg T, Eriksen M, Egeland T, Ilebekk A. Cardiac accumulation of bone marrow mononuclear progenitor cells after intracoronary or intravenous injection in pigs subjected to acute myocardial infarction with subsequent reperfusion. Cardiovascular Revascularization. 8 (2007) 21-27. https://doi.org/10.1016/j.carrev.2006.09.001
Bjornsson GL, Thorsteinsson L, Gudmundsson KO, Jonsson H Jr, Gudmundsson S, Gudbjornsson B. Inflammatory cytokines in relation to adrenal response following total hip replacement. Scand J Immunol. 2007 Jan;65(1):99-105. https://doi.org/10.1111/j.1365-3083.2006.01872.x
Halldórsdóttir AM, Zehnbauer BA, Burack WR. Application of BIOMED-2 clonality assays to formalinfixed paraffin embedded follicular lymphoma specimens: superior performance of the IGK assays compared to IGH for suboptimal specimens. Leuk Lymphoma. 2007 Jul;48(7):1338-43. https://doi.org/10.1080/10428190701377022
2006
Manfredsdottir VF, Vikingsdottir T, Jonsson T, Geirsson AJ, Kjartansson O, Heimisdottir M, Sigurdardottir SL, Valdimarsson H, Vikingsson A. The effects of tobacco smoking and rheumatoid factor seropositivity on disease activity and joint damage in early rheumatoid arthritis. Rheumatology (Oxford). 2006 Jun;45(6):734-40. https://doi.org/10.1093/rheumatology/kei240
Halldórsdóttir AM, Zhang L, Tollefsen DM., N-Acetylgalactosamine 4,6-O-sulfate residues mediate binding and activation of heparin cofactor II by porcine mucosal dermatan sulfate. Glycobiology. 2006 Aug;16(8):693-701. Epub 2006 Apr 19. https://doi.org/10.1093/glycob/cwj117
2005
Sigurjonsson OE, Perreault M-C, Egeland T, Glover JC. Human hematopoietic stem cells produce functional neurons efficiently in regenerating chicken embryo spinal cord. Proc. Natl. Acad. Sci. U S A. 2005 Apr; 102(14):5227-5232. https://doi.org/10.1073/pnas.0501029102
Boquest AC, Shahdadfar A, Fronsdal K, Sigurjonsson OE, Tunheim SH, Collas P, Brinchmann JE. Isolation and Transcription Profiling of Purified Uncultured Human Stromal Stem Cells: Alteration of Gene Expression Following In Vitro Cell Culture. Mol. Biol. Cell. 2005 Mar; 16(3): 1131-41. https://doi.org/10.1091/mbc.e04-10-0949
Thórarinsdóttir HK, Lúdvíksson BR, Víkingsdóttir T, Leópoldsdóttir MO, Ardal B, Jónsson T, Valdimarsson H, Arason GJ. Childhood levels of immunoglobulins and mannan-binding lectin in relation to infections and allergy. Scand J Immunol. 2005 May;61(5):466-74. https://doi.org/10.1111/j.1365- 3083.2005.01588.x
Halldórsdóttir AM, Stoker J, Porche-Sorbet R, Eby CS. Soluble CD40 ligand measurement inaccuracies attributable to specimen type, processing time, and ELISA method. Clin Chem. 2005 Jun;51(6):1054-7. https://doi.org/10.1373/clinchem.2005.048199
2004
Sigurjonsson OE, Gudmundsson KO, Haraldsdottir V, Rafnar T, Gudmundsson S. Flt3/Flk-2-Ligand in Combination With Thrombopoietin Delays Maturation and Decreases Apoptosis of Megakaryocyte Progenitor Cells Differentiated from Bone Marrow CD34+ cells in vitro. Stem Cells Dev. 2004 Apr; 13(2):
183-91. https://doi.org/10.1089/154732804323046783Stray-Pedersen A, Jónsson T, Heiberg A, Lindman CR, Widing E, Aaberge IS, Borresen-Dale AL, Abrahamsen TG. The impact of an early truncating founder ATM mutation on immunoglobulins, specific antibodies and lymphocyte populations in ataxia-telangiectasia patients and their parents. Clin Exp Immunol 2004 Jul;137(1):179-86. https://doi.org/10.1111/j.1365-2249.2004.02492.x
2003
Gudmundsson KG, Jónsson T, Arngrímsson R. Guillaume Dupuytren and finger contractures. Lancet. 2003 Jul 12;362(9378):165-8. https://doi.org/10.1016/s0140-6736(03)13871-8
Halldorsdottir AM, Carayannopoulos MO, Scrivner M, Gronowski AM. Method evaluation for total betahuman chorionic gonadotropin using urine and the ADVIA Centaur. Clin Chem. 2003 Aug;49(8):1421-2. https://doi.org/10.1373/49.8.1421
Halldórsdóttir AM, Sigurdardóttrir M, Jónasson JG, Oddsdóttir M, Magnússon J, Lee JR, Goldenring JR. Spasmolytic polypeptide-expressing metaplasia (SPEM) associated with gastric cancer in Iceland. Dig Dis Sci. 2003 Mar;48(3):431-41. https://doi.org/10.1023/a:1022564027468
2002
Gudmundsson KO, Sigurjonsson OE, Gudmundsson S, Goldblatt D, Weemaes CMR, Haraldsson A. Increased expression of Interleukin-13 but not Interleukin-4 in CD4+ cells from patients with the hyper IgE syndrome. Clin Exp Immunol. 2002 Jun; 128(3):532-7. https://doi.org/10.1046/j.1365- 2249.2002.01870.x
Sigurjonsson OE, Gudmundsson KO, Haraldsdottir V, Rafnar T, Gudmundsson S. Flt3/Flk-2-Ligand in Synergy with Thrombopoietin Delays Megakaryocyte Development and Increases the Numbers of Megakaryocyte Progenitor Cells in Serum-Free Cultures Initiated with CD34+ Cells. J. Hematotherapy and Stem Cell Research. 2002; 11: 389-400. https://doi.org/10.1089/152581602753658574
Gudmundsson KG, Arngrímsson R, Sigfússon N, Jónsson T. Increased total mortality and cancer mortality in men with Dupuytren's disease: a 15-year follow-up study. J Clin Epidemiol. 2002 Jan;55(1):5-10. https://doi.org/10.1016/s0895-4356(01)00413-9
2001
Sigurjónsson OE, Guðmundsson KO, Guðmundsson S. Mesenchymal stem cells. A review Laeknabladid. 2001 July/August;87(7/8):627-632. https://www.laeknabladid.is/2001/7/fraedigreinar/nr/967
1999
Gudmundsson KO, Thorsteinsson L, Gudmundsson S, Haraldsson A. Immunoglobulin-secreting cells in cord blood: effects of Epstein-Barr virus and interleukin-4. Scand J Immunol. 1999; 50(1):21-4. https://doi.org/10.1046/j.1365-3083.1999.00553.x
1998
Thorsteinsson L, O'Dowd GM, Harrington PM, Johnson PM.The complement regulatory proteins CD46 and CD59, but not CD55, are highly expressed by glandular epithelium of human breast and colorectal tumour tissues. APMIS. 1998;106(9):869-78. https://doi.org/10.1111/j.1699-0463.1998.tb00233.x
Gudmundsson KO, Thorsteinsson L, Haraldsson A, Gudmundsson S. [Hematopoietic stem cell grafts.] Læknablaðið. 1998; 84(5):373-379. https://www.hirsla.lsh.is/bitstream/handle/2336/49414/L1998-05-84-F1.pdf?sequence=1&isAllowed=y
Asgeirsson B, Haebel S, Thorsteinsson L, Helgason E, Gudmundsson KO, Gudmundsson G, Roepstorff P. Hereditary cystatin C amyloid angiopathy: monitoring the presence of the Leu-68-->Gln cystatin C variant in cerebrospinal fluids and monocyte cultures by MS. Biochem J. 1998 ;329 ( Pt 3):497-503. https://dx.doi.org/10.1042%2Fbj3290497
1997
Wang ZZ, Jensson O, Thorsteinsson L, Vinters HV. Microvascular degeneration in hereditary cystatin C amyloid angiopathy of the brain. APMIS. 1997;105(1):41-7. https://doi.org/10.1111/j.1699- 0463.1997.tb00538.x
1996
Yamada M, Itoh Y, Shintaku M, Kawamura J, Jensson O, Thorsteinsson L, Suematsu N, Matsushita M, Otomo E. Immune reactions associated with cerebral amyloid angiopathy. Stroke. 1996;27(7):1155-62. Olafsson I, Thorsteinsson L, Jensson O. The molecular pathology of hereditary cystatin C amyloid angiopathy causing brain hemorrhage. Brain Pathol. 1996 ;6(2):121-6. Review. https://doi.org/10.1161/01.str.27.7.1155
Emilsson V, Thorsteinsson L, Jensson O, Gudmundsson G.Human cystatin C expression and regulation by TGF-β1: implications for the pathogenesis of hereditary cystatin C amyloid angiopathy causing brain hemorrhage, Amyloid: Int. J. Exp. Clin. Invest. 1996; 3: 110-118. https://doi.org/10.1111/j.1750- 3639.1996.tb00795.x
1995
Thomas GR, Jensson O, Gudmundsson G, Thorsteinsson L, Cox DW. Wilson disease in Iceland: a clinical and genetic study. Am J Hum Genet. 1995;56(5):1140-6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801449/
Jensson O, Jonsdottir S. [Mild haemophilia A in Iceland.] Laeknabladid. 1995;81(6):477-483. https://europepmc.org/article/med/20065483
Fossdal R, Magnússon L, Weber JL, Jensson O. Mapping the locus of atrophia areata, a helicoid peripapillary chorioretinal degeneration with autosomal dominant inheritance, to chromosome 11p15. Hum Mol Genet. 1995;4(3):479-83. https://doi.org/10.1093/hmg/4.3.479
1994
Ogmundsdóttir HM, Jóhannesson GM, Sveinsdóttir S, Einarsdóttir S, Hegeman A, Jensson O, Ogmundsdóttir HM. Familial macroglobulinaemia: hyperactive B-cells but normal natural killer function. Scand J Immunol. 1994;40(2):195-200. https://doi.org/10.1111/j.1365-3083.1994.tb03450.x
Newton R, Stanier P, Loughna S, Henderson DJ, Forbes SA, Farrall M, Jensson O, Moore GE. Linkage analysis of 62 X-chromosomal loci excludes the X chromosome in an Icelandic family showing apparent X-linked recessive inheritance of neural tube defects. Clin Genet. 1994;45(5):241-9. https://doi.org/10.1111/j.1399-0004.1994.tb04149.x
Jørgensen J, Jensson O, Eklund J, Kornstad L, Messeter L. [Transfusion medicine--Scandinavian recommendations]. Nord Med. 1994;109(2):61-3. https://pubmed.ncbi.nlm.nih.gov/8121792/
Jensson O, Stenbjerg Bernvil S, Jónsdóttir S, Ingerslev J. Mild haemophilia A in Iceland: clinical genetic studies of three families with the same mutation. J Intern Med. 1994;235(5):443-50. https://doi.org/10.1111/j.1365-2796.1994.tb01101.x
Hol FA, Geurds MP, Jensson O, Hamel BC, Moore GE, Newton R, Mariman EC. Exclusion mapping of the gene for X-linked neural tube defects in an Icelandic family. Hum Genet. 1994;(4):452-6. https://doi.org/10.1007/bf00201674
Haan J, Maat-Schieman ML, van Duinen SG, Jensson O, Thorsteinsson L, Roos RA. Co-localization of beta/A4 and cystatin C in cortical blood vessels in Dutch, but not in Icelandic hereditary cerebral hemorrhage with amyloidosis. Acta Neurol Scand. 1994; 89(5):367-71. https://doi.org/10.1111/j.1600- 0404.1994.tb02648.x
1993
Fossdal R, Böthvarsson M, Asmundsson P, Ragnarsson J, Peters D, Breuning MH, Jensson O. Icelandic families with autosomal dominant polycystic kidney disease: families unlinked to chromosome 16p13.3 revealed by linkage analysis. Hum Genet. 1993;91(6):609-13. https://doi.org/10.1007/bf00205089
1992
Ogmundsdóttir HM, Thorsteinsson L, Sigfússon A, Sveinsdóttir S, Björnsson S, Eyjólfsson G, Jóhannesson GM, Jensson O. Natural killer cell function and malignant cell phenotype in hairy cell leukaemia. APMIS. 1992 ;100(1):10-20. https://doi.org/10.1111/j.1699-0463.1992.tb00834.x
Jonsdottir S, Diamond C, Levinson B, Magnusson S, Jensson O, Gitschier J.
Missense mutations causing mild hemophilia A in Iceland detected by denaturing gradient gel electrophoresis. Hum Mutat. 1992;1(6):506-8. https://doi.org/10.1002/humu.1380010610Thorsteinsson L, Georgsson G, Asgeirsson B, Bjarnadóttir M, Olafsson I, Jensson O, Gudmundsson G. On the role of monocytes/macrophages in the pathogenesis of central nervous system lesions in hereditary cystatin C amyloid angiopathy. J Neurol Sci. 1992 ;108(2):121-8.
Abrahamson M, Jonsdottir S, Olafsson I, Jensson O, Grubb A. Hereditary cystatin C amyloid angiopathy: identification of the disease-causing mutation and specific diagnosis by polymerase chain reaction based analysis. Hum Genet. 1992;89(4):377-80.
1991
Eklund J, Jørgensen J, Högman C, Jensson O, Kornstad L. Scandinavian recommendations for transfusion medicine. Nord Med. 1991;106(11):299-300. https://pubmed.ncbi.nlm.nih.gov/1945807/
Moore GE, Williamson R, Jensson O, Chambers J, Takakubo F, Newton R, Balacs MA, Ivens A. Localization of a mutant gene for cleft palate and ankyloglossia in an X-linked Icelandic family. J Craniofac Genet Dev Biol. 1991; 11(4):372-6. https://pubmed.ncbi.nlm.nih.gov/1687471/
1990 og eldra
Thorsteinsson L, Ogmundsdóttir HM, Sigfússon A, Arnason A, Eyjólfsson G, Jensson O. The first Icelandic family with X-linked agammaglobulinaemia: studies of genetic markers and immune function. Scand J Immunol. 1990 ;32(3):273-80. https://doi.org/10.1111/j.1365-3083.1990.tb02920.x
Palsdottir A, Jonsdottir S, Abrahamson M, Grubb A, Jensson O. Three RFLPs at the 3' end of the cystatin C gene, the disease gene in hereditary cystatin C amyloid angiopathy (HCCAA) in Iceland. Nucleic Acids Res. 1990 18(24):7471. https://doi.org/10.1093/nar/18.24.7471-a
Eklund J, Jørgensen J, Högman C, Jensson O, Kornstad L. [Recommendations from the 12th Scandinavian meeting on transfusion medicine]. Nord Med. 1990;105(4):119-20.
https://pubmed.ncbi.nlm.nih.gov/2111542/Abrahamson M, Olafsson I, Palsdottir A, Ulvsbäck M, Lundwall A, Jensson O, Grubb A. Structure and expression of the human cystatin C gene. Biochem J. 1990 ;268(2):287-94. https://doi.org/10.1042/bj2680287
Fujihara S. et al. (1990) Cystatin C (γ-Trace) and β-Protein Coexist in the Cerebral Amyloid Angiopathy Causing Cerebral Hemorrhage and Consequential Vascular Dementia. In: Nagatsu T., Fisher A., Yoshida M. (eds) Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s
Diseases. Advances in Behavioral Biology, vol 38A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5844-2_23
Garred P, Mollnes TE, Thorsteinsson L, Erlendsson K, Steinsson K. Increased amounts of C4-containing immune complexes and inefficient activation of C3 and the terminal complement pathway in a patient with homozygous C2 deficiency and systemic lupus erythematosus. Scand J Immunol. 1990 Jan;31(1):59- 64. https://doi.org/10.1111/j.1365-3083.1990.tb02743.x
Jensson O, Palsdottir A, Thorsteinsson L, Arnason A, Abrahamson M, Olafsson I, Grubb A. Cystatin C mutation causing amyloid angiopathy and brain hemorrhage.Biol Chem Hoppe Seyler. 1990 May;371 Suppl:229-32. https://pubmed.ncbi.nlm.nih.gov/2169252/
Moore GE, Ivens A, Newton R, Balacs MA, Henderson DJ, Jensson O. X chromosome genes involved in the regulation of facial clefting and spina bifida. Cleft Palate J. 1990;27(2):131-5. Review. https://doi.org/10.1597/1545 1569(1990)027%3C0131:xcgiit%3E2.3.co;2
Olafsson I, Gudmundsson G, Abrahamson M, Jensson O, Grubb A. The amino terminal portion of cerebrospinal fluid cystatin C in hereditary cystatin C amyloid angiopathy is not truncated: direct sequence analysis from agarose gel electropherograms. Scand J Clin Lab Invest. 1990;50(1):85-93. https://doi.org/10.1080/00365519009091569
Yamada M, Tsukagoshi H, Wada Y, Otomo E, Hayakawa M, Thorsteinsson L, Jensson O. Absence of the cystatin C amyloid in the cerebral amyloid angiopathy, senile plaque, and extra-CNS amyloid deposits of aged Japanese. Acta Neurol Scand. 1989 ;79(6):504-9. https://doi.org/10.1111/j.1600- 0404.1989.tb03822.x
Palsdottir A, Thorsteinsson L, Jonsdottir S, Arnason A, Snaedal J, Magnusson T, Snorrason E, Ingibergsdottir R, Abrahamson M, Olafsson I, et al. Study of restriction fragment length polymorphism in the cystatin C gene of elderly patients with dementia and aged Down's syndrome patients. Prog Clin Biol Res. 1989;317:235-9. https://pubmed.ncbi.nlm.nih.gov/2574869/
Mutation in the cystatin C gene causes hereditary brain hemorrhage. Palsdottir A, Abrahamson M, Thorsteinsson L, Arnason A, Olafsson I, Grubb A, Jensson O. Prog Clin Biol Res. 1989;317:241-6. https://pubmed.ncbi.nlm.nih.gov/2602420/
Jensson O, Palsdottir A, Thorsteinsson L, Arnason A. The saga of cystatin C gene mutation causing amyloid angiopathy and brain hemorrhage--clinical genetics in Iceland. Clin Genet. 1989;36(5):368-77. Review. https://doi.org/10.1111/j.1399-0004.1989.tb03215.x
Högman C, Jensson O, Eklund J, Kornstad L, Jörgensen J. [Norwegian propositions for blood transfusion practices]. Nord Med. 1989;104(3):83-4. https://pubmed.ncbi.nlm.nih.gov/2922255/
Mutation in cystatin C gene causes hereditary brain haemorrhage. Palsdottir A, Abrahamson M, Thorsteinsson L, Arnason A, Olafsson I, Grubb A, Jensson O. Lancet. 1988 Sep 10;2(8611):603-4. doi: 10.1016/s0140-6736(88)90641-1.
https://doi.org/10.1016/s0140-6736(88)90641-1Thorsteinsson, L, Blöndal, H, Jensson, O and Gudmundsson, G (1988). Distribution of cystatin C amyloid deposits in the Icelandic patients with hereditary cystatin C amyloid angiopathy In Amyloid and Amyloidosis, Proceedings of the Vth International Symposium on Amyloidosis, held in Hakone Japan. (T Isobe, Araki S, Uchino F, Kito S, Tsubura E. (Eds) Plenum Press New York: pp 585-590. https://link.springer.com/chapter/10.1007/978-1-4757-0298-9_98
Moore G, Ivens A, Chambers J, Bjornsson A, Arnason A, Jensson O, Williamson R. The application of molecular genetics to detection of craniofacial abnormality. Development. 1988;103 Suppl:233-9. https://pubmed.ncbi.nlm.nih.gov/3074911/
Jensson, O, Thorsteinsson, L, Palsdottir, A, Gudmundsson, G, Arnason, A, Blöndal, H, Abrahamson, M, Grubb, A, Olafsson, I and Lundwall, Å (1988). An isolate of families in the South of Iceland suspected of hereditary cystatin C amyloid angiopathy In Amyloid and amyloidosis, (Isobe T., Araki S., Uchino F., Kito S. andTsubura E,. Eds) New York: Plenum, pp 579-584.
Jensson O, Arnason A, Gunnarsdottir H, Petursdottir I, Fossdal R, Hreidarsson S. A family showing apparent X linked inheritance of both anencephaly and spina bifida. J Med Genet. 1988;25(4):227-9. https://doi.org/10.1136/jmg.25.4.227
Ivens A, Moore GE, Chambers J, Arnason A, Jensson O, Bjornsson A, Williamson R. X-linked cleft palate: the gene is localized between polymorphic DNA markers DXYS12 and DXS17. Hum Genet. 1988 ;78(4):356-8. https://doi.org/10.1007/bf00291735
Palsdóttir Á, Jensson O, Gudmundsson G, Arnason A, Abrahamson M, Grubb A, Ólafsson Í, Lundvall Ǻ. Studies on the cystatin C in patients with hereditary cystatin C amyloid angiopathy (HCCAA) with cerebral haemorrhage. In Amyloid and amyloidosis, Proceedings of the Vth International Symposium on Amyloidosis, held October 25-28, 1987 in Hakone, Japan. Isobe T, Araki S, Uchino F, Kito S, Tsubura E.(eds) New York: Plenum, pp 591-96. https://link.springer.com/chapter/10.1007/978-1-4757-0298-9_99
Palsdottir A, Fossdal R, Jensson O, Arnason A. Bgl II polymorphic site upstream to the human complement component C4A gene. Nucleic Acids Res. 1987;15(5):2395.
https://doi.org/10.1093/nar/15.5.2395Palsdottir A, Fossdal R, Arnason A, Edwards JH, Jensson O. Heterogeneity of human C4 gene size. A large intron (6.5 kb) is present in all C4A genes and some C4B genes. Immunogenetics. 1987;25(5):299-304. https://doi.org/10.1007/bf00404422
Palsdottir A, Arnason A, Fossdal R, Jensson O. Gene organization of haplotypes expressing two different C4A allotypes. Hum Genet. 1987;76(3):220-4. https://doi.org/10.1007/bf00283611
Moore GE, Ivens A, Chambers J, Farrall M, Williamson R, Page DC, Bjornsson A, Arnason A, Jensson O. Linkage of an X-chromosome cleft palate gene. Nature. 1987;326(6108):91-2. https://doi.org/10.1038/326091a0
Löfberg H, Grubb AO, Nilsson EK, Jensson O, Gudmundsson G, Blöndal H, Arnason A, Thorsteinsson L. Immunohistochemical characterization of the amyloid deposits and quantitation of pertinent cerebrospinal fluid proteins in hereditary cerebral hemorrhage with amyloidosis. Stroke. https://www.ahajournals.org/doi/10.1161/01.STR.18.2.4311987;18(2):431-40.
Jensson O, Gudmundsson G, Arnason A, Blöndal H, Petursdottir I, Thorsteinsson L, Grubb A, Löfberg H, Cohen D, Frangione B. Hereditary cystatin C (ga-14.mma-trace) amyloid angiopathy of the CNS causing cerebral hemorrhage. Acta Neurol Scand. 1987;76(2):102. https://doi.org/10.1111/j.1600- 0404.1987.tb03553.x
Jensson Ó. Vísindarannsóknir og íslensk læknisfræði. Athugasemdir við álitsgerð Snorra S. Þorgeirssonar og Stefáns Karlssonar. Læknablaðið 1986; 72: 210-11
Jensson Ó, Gudmundsson G, Árnason A, Blöndal H, Grubb A, Löfberg H. Herditary central nervous system γ-trace amyloid angiopathy and stroke in iIcelandic families. In Amyloidosis GG Glenner, EF Osserman, EP Benditt, E Calkins, AS Cohen, D Zucker-Franklin (eds). Proceedings of the Fourth International Symposium on Amyloidosis. The Disease Complex held Novem,ber 9-12, 1984 qtr the Columbia University, New York, New York. Plenum press New York pp. 789-801, 1986. https://link.springer.com/chapter/10.1007/978-1-4613-2199-6_99
Ghiso J, Jensson O, Frangione B. Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of Icelandic type is a variant of gamma-trace basic protein (cystatin C). Proc Natl Acad Sci U S A. 1986;83(9):2974-8. https://doi.org/10.1073/pnas.83.9.2974
Cohen DH, Feiner H, Jensson Ó, Frangione B. Amyloid fibrils in herditary cerebral hemorrhage with amyloidosis. (HCHWA) is related to cystatin (gamma trace) In Amyloidosis GG Glenner, EF Osserman, EP Benditt, E Calkins, AS Cohen, D Zucker-Franklin (eds). Proceedings of the Fourth International Symposium on Amyloidosis. The Disease Complex held Novem,ber 9-12, 1984 qtr the Columbia University, New York, New York. Plenum press New York pp. 761-766 1986. https://link.springer.com/chapter/10.1007/978-1-4613-2199-6_96Guðmundsson G, Jensson Ó, Arnason A, Stfánsson K. Huntingstonveiki á Íslandi. Fjölrit 1985 Þorsteinsson L. Jensson Ó. Sigurðsson B. Árnason A. Ónæmisathuganir á blæðurum með dreyrasýki A. Læknablaðið 1985; 71: 117-22
Rowe IF, Jensson O, Lewis PD, Candy J, Tennent GA, Pepys MB. Immunohistochemical demonstration of amyloid P component in cerebro-vascular amyloidosis.Neuropathol. and Appl. Neurobiol. 1984;10(1):53- 61. https://doi.org/10.1111/j.1365-2990.1984.tb00340.x
Grubb A, Jensson O, Gudmundsson G, Arnason A, Löfberg H, and Malm J. Abnormal metabolism of gamma-trace alkaline microprotein. The basic defect in hereditary cerebral hemorrhage with amyloidosis. N Engl J Med. 1984;311(24):1547-9. https://doi.org/10.1056/nejm198412133112406
Hansson BG, Norkrans G, Weibull M, Weiland O, Nielsen J, Leinikki P, Ukkonen P, Jensson O, Siebke JC. Epidemiology of delta infection in Scandinavia. Prog Clin Biol Res. 1983;143:155-9. https://pubmed.ncbi.nlm.nih.gov/6669568/
Jensson Ó Blóðbankinn 30 ára 1953-1983 Sérprent Reykjavík 16 bls 1983
Karlsson S, Skaftadóttir I, Arnason A, Mackintosh P, Jensson O. Gc subtypes in Northern Indians. Hum Hered. 1983;33(3):199-200. https://doi.org/10.1159/000153377Cohen DH, Feiner H, Jensson O, Frangione B. Amyloid fibril in hereditary cerebral hemorrhage with amyloidosis (HCHWA) is related to the gastroentero-pancreatic neuroendocrine protein, gamma trace. J Exp Med. 1983 ;158(2):623-8. https://doi.org/10.1084/jem.158.2.623
Olafsdóttir S, Jensson O, Thordarson G, Sigurdardóttir S. An unusual Rhesus haplotype, --D--, in Iceland. Forensic Sci Int. 1983;22(2-3):183-7. https://doi.org/10.1016/0379-0738(83)90012-9 Jensson Ó, Árnason A, Skaftadóttir I, Linnet H.A, Jómundsson G Snorradóttir M. Arfgeng marmara beinveiki (osteoporosis) í ungbörnum. Læknablaðið 1983; 69: 35-41. https://doi.org/10.1111/j.0954- 6820.1982.tb01959.x Gc subtypes in Icelanders.
Karlsson S, Skaftadóttir I, Arnason A, Thórdarson G, Jensson O. Hum Hered. 1983;33(1):5-8. https://doi.org/10.1159/000153339
Jensson O, Björnsson O G, Arnason A, Birgisdóttir B, Pepys MB. Serum amyloid P-component and Creactive protein in serum of healthy Icelanders and members of an Icelandic family with macroglobulinaemia. Acta Med Scand. 1982;211(5):341-5. https://doi.org/10.1111/j.0954- 6820.1982.tb01959.x
Ulfarsson J, Gudmundsson S, Birgisdóttir B, Kjeld JM, Jensson O. Selective serum IgA deficiency in Icelanders. Frequency, family studies and Ig levels. Acta Med Scand. 1982;211(6):481-7. https://pubmed.ncbi.nlm.nih.gov/7113764/
Úlfarsson J., J Guðmundsson S., Birgisdóttir B., Kjeld M. og Jensson Ó. IgA skortur í sermi Íslendinga, rannsóknir á tíðni og fjölskyldum. Læknablaðið 1982; 68: 22-30.
Víkingsson K.K., Hallgrímsson J., Baldvinsson E. og Jensson Ó. Aneurysma diseases í þremur ættliðum. Læknablaðið 1982; 68: 292-5Theodórs A, Sigurðsson BV, Jensson Ó. Blóðónæmisrannsóknir vegna rehusvarna: aðferðir Læknablaðið 1980; 66(fylgirit 10): 30-3
Ólafsdóttir S, Jensson Ó, Þórðarson G, Sigurðardóttir S. Óvenjulegur rhesusblóðflokkur. Læknablaðið. 1980; 66: 209-11.
Jonsdottir S, Diamond C, Levinson B, Magnusson S, Jensson O, Gitschier J. Karlsson S, Arnason A, Jensson O. GLO polymorphism in Iceland. Hum Hered. 1980;30(6):383-5. https://doi.org/10.1159/000153163
Lamm LU, Weitkamp LR, Jensson O, Pedersen GB, Kissmeyer-Nielsen F On the mapping of PGM3, GLO and HLA. Tissue Antigens. 1978;11(2):132-8
Björnsson OG, Arnason A, Gudmunosson S, Jensson O, Olafsson S, Valdimarsson H.Macroglobulinaemia in an Icelandic family. Acta Med Scand. 1978;203(4):283-8.-9. https://doi.org/10.1111/j.1399- 0039.1978.tb01237.x
Guðmundsson S, Jensson Ó. Leit að lifrabólguveiru B hjá blóðgjöfum Læknablðaið 1978; 64: 91-5 Jensson Ó. Blóðbankinn 25 ára. Læknablaðið 1978; 64: 210-11
Jensson O. Studies on four hereditary blood disorders in Iceland (thesis).Acta Med Scand. 1978;204:1- 28.
Karlsson S. Þórarinsson H. og Jensson Ó. Sárasótt á Íslandi 1950-1975, tíðni blóðvatnsgreining. Læknablaðið 1978; 64: 173-81
Gudmundsson S, Jensson O. Frequency of IgA deficiency in blood donors and Rh negative women in Iceland. Acta Pathol Microbiol Scand C. 1977;85(2):87-9. https://doi.org/10.1111/j.1699- 0463.1977.tb03616.x
Jensson O, Jónasson JL, Magnússon S. Studies on herediatary spherocytosis in Iceland. Acta Pathol Microbiol Scand C. 1977;201:187-195. https://doi.org/10.1111/j.0954-6820.1977.tb15680.x
Jensson O, Arnason K, Jóhannesson GM, Ulfarsson J. Studies on the Pelger anomaly in Iceland. Acta Med Scand. 1977;201(3):183-5. https://pubmed.ncbi.nlm.nih.gov/848354/
Ólafsdóttir E , Arnason A. Tíðni afbrigðilegra cholinesterasa. Læknablaðið 1977; 63: 95-8Jensson Ó, Hauksdóttir H, Bjarnason Ó, Tulinius H. Yfirlit um litningarannsóknir 1967-1975. Læknablaðið 1976; 62: 127-30
Jensson Ó, Bjarnason Ó. Frumugreining á magakrabbameini . Læknablaðið 1975; 61: 51-9 Arnason A, Jensson O, Gudmundsson S. Serum esterases of Icelanders. I. A "silent" pseudocholinesterase gene in an Icelandic family. Clin Genet. 1975;7(5):405-12. https://doi.org/10.1111/j.1399- 0004.1975.tb00349.x
Jensson Ó. Blóðbankastarfsemi og blóðgjafir. Læknaneminn 1975; 28: 56-61.
Jensson Ó, KE Jónsdóttir. Viðbrögð við blóðtöku Læknaneminn 1975; 28: 25-27
Jensson Ó, Guðmundsson S. Amerísk-íslensk Pelger-fjölskylda. Læknablaðið 1974; 60: 81-3.
Árnason A, Jensson Ó, Guðmundsson S. Öndunarlömun af vöðvaslappandi lyfi vegna arfgengs skorts á serumcholinesterasa. Læknablaðið 1974; 60: 15-9
Þórarinsson AA, Jensson Ó, Bjarnason Ó. Krabbameinsleit hjá konum 1964-1970. Læknablaðið 1974; 60: 121-8.
Bjarnason O, Bjarnason V, Edwards JH, Fridriksson S, Magnusson M, Mourant AE, Tills D. The blood groups of Icelanders. Ann Hum Genet. 1973; 36(4): 425-58. https://doi.org/10.1111/j.1469- 1809.1973.tb00606.x
Jensson Ó. Viðfangsefni nútíma blóðbanka. Blað Meinatækna 1973; 3(1): 35-39.
1972 Hauksdóttir H, Halldórsson S, Jensson O, Mikkelsen M, McDermott A. Pericentric enversion of chromosome no. 13 in a large family leading to duplication deficiency causing congenital malformations in three individuals. J Med Genet. 1972; 9(4):413-21. https://dx.doi.org/10.1136%2Fjmg.9.4.413Kaur J, Catovsky D, Valdimarsson H, Jensson O, Spiers AS. Familial acute myeloid leukaemia with acquired Pelger-Huet anomaly and aneuploidy of C group. Br Med J. 1972 ;4(5836):327-31. https://doi.org/10.1136/bmj.4.5836.327
Jensson Ó. Um nauðsyn lyfjakorta. Læknablaðið 1972; 58;68 1970
Jensson O, Wallett LH Von Willebrand's disease in an Icelandic family. Acta Med Scand. 1970;187(3):229- 34. https://doi.org/10.1111/j.0954-6820.1970.tb02936.x
Jensson O. Surveys of human genetics 65o Icelandic Life 1970; 10: 23-25 og 28
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Útskrifaðir nemar
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Dr. Sandra Mjöll Jóndsóttir Buch. Osteogenesi and osteoimmunology of hES-MP derived osteoblasts: The potential of platelet lysates as serum substitute. Department of medicine University of Iceland. 2017
Dr. Magdalena Stefaniak. Bioactive properties of polysaccharides derived from Icelandic marine organisms. Department of food sciences University of Iceland. 2018
Dr. Joseph Lovecchio. University of Bologna/ Reykjavik University. Design and construction of a bioreactor system for bone formation. Department of Science and Engineering Reykjavik University. 2018.
Dr. Freyr Jóhansson. Systems analysis of platelet metabolism during storage of platelet concentrates. Department of medicine University of Iceland. 2020
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Dr. Adriana Milewska. Thesis: Development of SERS substrates for detecting differentiation in mesenchymal stromal cells. University of Iceland. 2021
Dr. Níels Árni Árnason. Project. The effect of pathogen inactivation on storage and physiology of platelets. (graduation in 2022). Reykajvik University
Dr. Anna Þóra Hrólfsdóttir. Thesis.Bioactivity of marine sidestream. University of Iceland. (graduated in 2024). University of Iceland.
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Karen Gunnarsdóttir: Lipidomics in Osteogenic and Adipogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells. Department of Medicine, University of Iceland. (Graduated 2024)
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Magda Ostrowska Magnesium infused biphasic calcium phosphate and chitosan grafted on glass as scaffolds for mesenchymal stem cells culture. Gdansk University of technology. 2016
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Benjamín Sigurgeirsson. Sleep-Wake Modulation of Gene Expression in Zebrafish. School of science and engineering, Reykjavík University. 2013
Helga Einarsdóttir. Arfgengar orsakir einstofna mótefnahækkunar og skyldra B-frumusjúkdóma. Department of medicine University of Iceland. 2009
Ramona Lieder. Chitinase-like-Proteins in Mesenchymal Stromal Cells and Bone Development. Ramona Lieder. F/H Campus Wien. 2009.
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Kristín Erla Harðardóttir. Þeim rennur blóðið til skyldunnar: Blóðgjafir Íslendinga í mannfræðilegu ljósi. Háskóli Íslands, Félagsvísindadeild. 2002
Ólafur E. Sigurjónsson. Megakaryocyte development in vitro: Differentiation, ploidy and apoptosis. Department of medicine, University of Iceland. Leiðbeinendur: Sveinn Guðmundsson, Vilhelmína Haraldsdóttir. 2001.
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Kristbjörg Gunnarsdóttir. The effect of expanding mesenchymal stem cells in media supplemented with lysate manufactured from fresh or expired platelet concentrates on chondrogenic differentiation. Department of medicine, University of Iceland. 2013
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Salóme Ingólfsdóttir. The effect of expanding mesenchymal stem cells in media supplemented with lysate manufactured from fresh or expired platelet concentrates on chondrogenic differentiation. Department of medicine, University of Iceland. 2012
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Gunnar Bollason. Greining rauðkornamótefna kvenna á Íslandi árin 1996-2015. Áhrif á meðgöngu og afdrif nýbura. Læknadeild, Háskóli Íslands. 2016
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Myndband um rannsóknir í Blóðbankanum
Ólafur Eysteinn, forstöðumaður Blóðbankans, segir frá þeim rannsóknum sem gerðar eru í Blóðbankanum. Hann hlaut rannsóknarverðlaun HR árið 2020.